Volume 2,Issue 1
Fall 2025
基于网络药理学和实验研究验证唾液酸在燕窝提取物中的抗衰老和抗炎活性表现
通过文献调研和网络药理学分析,从燕窝提取物中鉴定出33种有效成分,预测471个靶点,发现唾液酸为核心成分,与抗炎和抗衰老通路相关。通过斑马鱼中性粒细胞聚集模型和基因表达模型,研究了不同浓度唾液酸燕窝提取物的抗炎和抗皱效果。结果显示,燕窝提取物显著抑制中性粒细胞聚集(98%~100%),抗皱紧致效果显著,尤其在高唾液酸浓度下。人体测试也验证了其舒缓和抗皱效果,能有效缓解皮肤炎症和紧致肌肤。
[1]林洁茹,周华,赖小平.燕窝研究概述[J].中药材,2006(01):85-90.
[2]赵小依,方佳豪,郭怡君,等.燕窝神经保护作用研究进展[J].食品与发酵工业,2024,50(20):367-374.DOI:10.13995/j.cnki.11-1802/ts.040206.
[3]王梦花,林小仙,琚萌萌等.唾液酸的制备和生物活性研究进展[J]. 药学研究,2022,41(09):600-604.
[4] 喻雨琴,朱新芳 ·燕窝及其制品的气相色谱鉴别和定量检测.分析测试学报,1998, 17(6):33-36.
[5]王羚郦,李远彬,邱子博等.25种燕窝样品中唾液酸含量的测定与分析[J]. 中国实验方剂学杂志,2013,19(19):64-67.
[6]阙茂垚,张晓婷,柳训才,等.燕窝营养成分分析与品质综合评价[J].食品安全导刊,2021,(32):92-95.DOI:10.16043/j.cnki.cfs.2021.32.044.
[7]Hwang E., Park S. W., Yang J. E. Anti-aging, anti-inflammatory,and wound-healing activities of edible bird’s nest in human skin keratinocytes and fibroblasts. Pharmacogn. Mag., 16 (2020) 336.
doi:10.4103/pm.pm_326_19.
[8]Görög P., Kovács I. B. Anti-inflammatory effect of sialic acid.Agents Actions 8(5) (1978) 543–545. doi:10.1007/BF02111443.
[9]李翠,徐小涵,林小仙,等.燕窝营养成分与功效研究现状[J/OL].食品与发酵工业,1-9[2024-12-07].https://doi.org/10.13995/j.cnki.11-1802/ts.037340.
[10] Mastrogiovanni M, Martínez-Navarro FJ, Bowman TV, Cayuela ML. Inflammation in Development and Aging: Insights from the Zebrafish Model. Int J Mol Sci. 2024 Feb 10;25(4):2145. doi: 10.3390/
ijms25042145.
[11] Gistelinck C, Gioia R, Gagliardi A, Tonelli F, Marchese L, Bianchi L, Landi C, Bini L, Huysseune A, Witten PE, Staes A, Gevaert K, De Rocker N, Menten B, Malfait F, Leikin S, Carra S, Tenni R, Rossi A, De Paepe A, Coucke P, Willaert A, Forlino A. Zebrafish Collagen Type I: Molecular and Biochemical Characterization of the Major Structural Protein in Bone and Skin. Sci Rep. 2016 Feb 15;6:21540. doi: 10.1038/srep21540.
[12] Miao M, Bruce AE, Bhanji T, Davis EC, Keeley FW. Differential expression of two tropoelastin genes in zebrafish. Matrix Biol. 2007 Mar;26(2):115-24. doi: 10.1016/j.matbio.2006.09.011.
[13] Stuart K, Paderi J, Snyder PW, Freeman L, Panitch A. Collagenbinding peptidoglycans inhibit MMP mediated collagen degradation and reduce dermal scarring. PLoS One. 2011;6(7):e22139. doi: 10.1371/journal.pone.0022139. Epub 2011 Jul 11. PMID: 21779387; PMCID:PMC3133773.
[14] Jensen JM, Proksch E. The skin’s barrier. G Ital Dermatol Venereol. 2009 Dec;144(6):689-700. PMID: 19907407.
[15] Amaro-Ortiz A, Yan B, D’Orazio JA. Ultraviolet radiation,aging and the skin: prevention of damage by topical cAMP manipulation. Molecules. 2014 May 15;19(5):6202-19. doi: 10.3390/
molecules19056202. PMID: 24838074; PMCID: PMC4344124.
[16] Cao Y, Lv J, Tan Y, Chen R, Jiang X, Meng D, Zou K, Pan M, Tang L. Tribuloside acts on the PDE/cAMP/PKA pathway to enhance melanogenesis, melanocyte dendricity and melanosome
transport. J Ethnopharmacol. 2024 Apr 6;323:117673. doi: 10.1016/ j.jep.2023.117673. Epub 2023 Dec 27. PMID: 38158096.