Human Research

If human subjects were used in the experiments, authors must identify the committee or organization (e.g., author’s Institutional Ethics Review Board) approving the experiments in the Materials and Methods section of the manuscript, which should also detail ethics approval information such as the name of the granting committee or organization and the approval identifiers, i.e., reference numbers. Our journal requires that authors provide a proof of research ethics or ethics statement along with the submission. In the case that ethics approval identifiers are not available, written approval from the granting committee or organization must be provided as confidential supplementary file.

In the manuscript, include a statement in the Materials and Methods section confirming that the experiments were carried out in adherence to the ethical principles set out in the WMA Declaration of Helsinki or other relevant institutional and national guidelines and regulations, and that informed consent was obtained from all human subjects. For investigations undertaken on human subjects, the manner in which the informed consent was obtained from the study participants (i.e., oral or written) should be stated clearly as well.

The authors should inform the study participants of the purpose(s) of publication, the possible risks and benefits as a result of the experiment, and the patient's right to withhold or withdraw consent. Consent should be obtained from the parent(s) or legal guardian(s) if the study participant is a minor.

Authors are obliged to declare and clearly specify any restrictions on the availability or the use of human data in the manuscript.

Patient Anonymity and Privacy

Human subjects have a right to privacy that should not be violated without informed consent. Identifying information or patient identifiers, including patient names, initials, date of birth, contacts, medical record numbers, hospital numbers, and geographical location, should not be published in written descriptions, photographs, or pedigrees unless the information is essential for scientific purposes and the patient (parent or guardian) gives written informed consent for publication. Efforts must be made by the authors to at least mask or conceal any identifying information of the patients that appear in writing or within photograph.

Authors are obliged to explain to the patient if revealing the patient’s identity cannot be fully avoided, e.g., an image of an identifiable body part like the face has to be published in the report. The relevant identifying information to be published, e.g., the image, must be shown to the patient, and consent for publication taken for the use of that information in the publication. If the patient dies, then consent must be obtained from next of kin or legal representative. We shall consider author version of consent form for publication if all the essential items as shown in our sample consent form were included.

All submissions will be checked for documentation of patient consent for publication and for any potentially identifying information. Submissions that include identifying patient.

Animal Research

For studies describing testing on regulated animals (i.e., all live vertebrates and/or higher invertebrates), authors must identify the committee or organization (e.g., author’s Institutional Ethics Review Board) approving the experiments in the Materials and Methods section of the manuscript, which should also detail ethics approval information such as the name of the granting committee or organization and the approval identifiers, i.e., reference numbers. For research conducted on non-regulated animals, a statement should be made as to why ethical approval was not required. Our journal requires that authors provide a proof of research ethics or ethics statement along with the submission. In the case that ethics approval identifiers are not available, written approval from the granting committee or organization must be provided as confidential supplemental file.

Authors are encouraged to follow the ARRIVE guidelines while reporting animal research. In the manuscripts, any additional guidelines for the care and use of laboratory animals that were used in the experiment should be indicated. Briefly, the authors should also include animal details (e.g., species, gender, age, weight), animal housing conditions and husbandry information, and relevant steps taken to ameliorate pain and suffering of the animals in the Materials and Methods section.

Specifically, experiments on non-human primates must be performed in accordance with the recommendations set out in the Weatherall report (The Use of Non-Human Primates in Research).

Application of Cell Lines

To ensure research reproducibility, authors must declare what cell lines were used in their experiment and the source or origin of all cell lines utilized. It is advisable to provide information regarding the authentication of cell lines and testing for mycoplasma contamination.

Generation of de novo cell lines derived from human tissue must be approved by the relevant ethics committee (or author’s Institutional Ethics Review Board). Authors must identify the committee or organization (e.g. author’s Institutional Ethics Review Board) approving the experiments in the Materials and Methods section of the manuscript, which should also detail ethics approval information such as the name of the granting committee or organization and the approval identifiers, i.e., reference numbers. Our journal requires that authors provide a proof of research ethics or ethics statement along with the submission. In the case that ethics approval identifiers are not available, written approval from the granting committee or organization must be provided as confidential supplementary file. Authors must confirm that they obtained the consent from the donor or next of kin for deriving a cell line from the donor.