Volume 3,Issue 7
艾叶的多重药理活性及其临床应用研究进展
艾叶(Artemisia argyi Lévl.et Vant.)是一种具有多种药理活性和生物活性的植物药,主要成分包括黄酮类、酚酸类
和萜类化合物,具有抗炎、抗菌和免疫调节等作用。常用于治疗皮炎、心血管疾病及妇科疾病,同时被誉为“妇科圣
药”。其抗炎作用通过抑制MAPK/PI3K-AKT信号通路实现,显著减少炎症反应。近年来,艾叶在慢性疾病和肿瘤治
疗中的应用前景广阔,未来研究应重点关注其提取技术优化及临床联合用药的安全性。
[1]HAN X, SONG Y, HUANG R, et al. Anti-Inflammatory and Gut Microbiota Modulation Potentials of Flavonoids Extracted from Passiflora foetida Fruits [J]. Foods (Basel,
Switzerland), 2023, 12(15).
[2]DUAN L, ZHANG C, ZHANG C, et al. Green Extraction of Phenolic Acids from Artemisia argyi Leaves by Tailor-Made Ternary Deep Eutectic Solvents [J]. Molecules (Basel,
Switzerland), 2019, 24(15).
[3]CHEN L, ZHU Y, WANG Y, et al. The water-soluble subfraction from Artemisia argyi alleviates LPS-induced inflammatory responses via multiple pathways and targets in
vitro and in vivo [J]. Journal of ethnopharmacology, 2024, 319(Pt 3): 117364.
[4]WANG H, ZHANG Y, YU D, et al. A review of the research progress on Artemisia argyi Folium: botany, phytochemistry, pharmacological activities, and clinical
application [J]. Naunyn-Schmiedeberg's archives of pharmacology, 2024.
[5]ZHANG Z, FU X, WANG Y, et al. In vivo anti-hepatitis B activity of Artemisia argyi essential oil-loaded nanostructured lipid carriers. Study of its mechanism of action by
network pharmacology and molecular docking [J]. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2023, 116: 154848.
[6]ZENG K W, WANG S, DONG X, et al. Sesquiterpene dimer (DSF-52) from Artemisia argyi inhibits microglia-mediated neuroinflammation via suppression of NF-κB,
JNK/p38 MAPKs and Jak2/Stat3 signaling pathways [J]. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2014, 21(3): 298-306.
[7]WANG H, ZHANG M, MA Y, et al. Selective inactivation of Gram-negative bacteria by carbon dots derived from natural biomass: Artemisia argyi leaves [J]. Journal of
materials chemistry B, 2020, 8(13): 2666-72.
[8]SHI X S, SONG Y P, MENG L H, et al. Isolation and Characterization of Antibacterial Carotane Sesquiterpenes from Artemisia argyi Associated Endophytic Trichoderma
virens QA-8 [J]. Antibiotics (Basel, Switzerland), 2021, 10(2).
[9]LIU P, ZHONG L, XIAO J, et al. Ethanol extract from Artemisia argyi leaves inhibits HSV-1 infection by destroying the viral envelope [J]. Virology journal, 2023, 20(1): 8.
[10]XUE G M, ZHU D R, HAN C, et al. Artemisianins A-D, new stereoisomers of seco-guaianolide involved heterodimeric [4+2] adducts from Artemisia argyi induce
apoptosis via enhancement of endoplasmic reticulum stress [J]. Bioorganic chemistry, 2019, 84: 295-301.
[11]DüRR L, REINHARDT J K, DOBRZYŃSKI M, et al. A Dimerosesquiterpene and Sesquiterpene Lactones from Artemisia argyi Inhibiting Oncogenic PI3K/AKT Signaling
in Melanoma Cells [J]. Journal of natural products, 2022, 85(11): 2557-69.
[12] 李素芬, 黄燕. 滋肾育胎丸联合优思明对PCOS 不孕症患者子宫内膜容受性、内分泌指标及妊娠结局的影响 [J]. 贵州医科大学学报, 2024, 49(01): 151-6.
[13]WU Z X, CAI M J, HUANG P D, et al. Comparative efficacy and dysmenorrhea score of 6 object-separated moxibustions for the treatment of Chinese patients with
dysmenorrhea: A systematic review and network meta-analysis [J]. Medicine, 2021, 100(26): e26185.
[14]YUAN Q L, GUO T M, LIU L, et al. Traditional Chinese medicine for neck pain and low back pain: a systematic review and meta-analysis [J]. PloS one, 2015, 10(2):
e0117146.