Volume 3,Issue 9
中医药通过脑肠轴调控“肠道菌群-神经炎症-淀粉样蛋白”轴干预阿尔茨海默病的机制研究进展
阿尔茨海默病(AD)是一种常见的神经退行性疾病,以淀粉样蛋白(Aβ)沉积、Tau蛋白异常磷酸化及神经炎症为核心病理特征。近年研究发现,脑肠轴及其介导的“肠道菌群-神经炎症-Aβ”轴在AD发生发展中起关键作用。中医药凭借“整体调节”和“多靶点干预”的优势,在调控该轴上显示出良好潜力。本文系统综述AD病理机制、脑肠轴作用及中医药通过调节肠道菌群、抑制神经炎症、干预Aβ代谢等多途径防治AD的机制,为AD的中医药治疗提供理论依据与新策略。
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