Art and Design / MRP / Volume 2 / Issue 4 / DOI: 10.61369/mrp.6115
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艾司氯胺酮对苏醒期躁动和谵妄影响的meta分析

姝然 刘1 芷萱 方2 凡铮 盖3 娜 王4
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1 1. 吉林大学白求恩第一医院, 1. 吉林大学白求恩第一医院
2 2. 吉林大学白求恩第一医院, 2. 吉林大学白求恩第一医院
3 3. 河北省承德县中医院, 3. 河北省承德县中医院
4 4. 吉林大学白求恩第一医院, 4. 吉林大学白求恩第一医院
MRP 2024 , 2(4), 17–20;
Published: 20 April 2024
© 2024 by the Author(s). Licensee Art and Design, USA. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC BY-NC 4.0) ( https://creativecommons.org/licenses/by-nc/4.0/ )
Abstract

目的 对艾司氯胺酮对苏醒期躁动和谵妄影响进行meta分析。方 法 检索英文数据库 2023年11月14日前发表的关于艾司氯胺酮应用和苏醒期躁动和谵妄关系的文献,计算效应指标OR值和95%CI。用漏斗图和egger法评估发表偏倚。用TSA9.0进行试验序贯分析。结 果 META分析结果显示接受艾司氯胺酮的患者术后躁动的发生率显著降低(OR = 0.2, 95%CI [0.11; 0.37], I2 = 0%)术后谵妄的发生率显著降低(OR = 0.32, 95% CI [0.71; 0.60], I2 =0%)。且试验序贯分析进一步肯定了meta分析的结果。结论无论剂量、使用的给药模式或手术类型如何,围术期输注艾司氯胺酮可以降低术后躁动和谵妄的发生率。

Keywords
艾司氯胺酮
术后躁动
术后谵妄
Meta
试验序贯分析
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Medical Research and Practice, Electronic ISSN: 2993-9704 Print ISSN: 2993-9690, Published by Art and Design