Volume 3,Issue 9
天然磷脂和合成磷脂及其衍生物在药品生产中的应用
磷脂为含有元素磷的脂质,其分子结构中含亲水性基团和亲脂性支链,是具有表面活性的两亲性分子,可作为脂溶性药物生产中的乳化剂、增溶剂或脂质体赋形剂。相对于合成磷脂而言,天然磷脂来源于可再生资源,且生产、纯化工艺对环境更加友好,因此在口服制剂、真皮和非肠道用药制剂包括脂质体中应该十分广泛;合成磷脂的使用率则较低。在选择药物制剂的磷脂赋形剂方面,天然磷脂的优势更加明显,一方面其质量重现性良好,商品成本较低,另一方面天然磷脂来源于动物源,其安全性更容易被监管机构接受。为了避免在药物开发和生产过程中出现规模扩大的问题,应尽可能选择天然磷脂赋形剂而不是合成磷脂。
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