同源盒基因MEOX2在结直肠癌中的表达情况

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Abstract

目的研究结直肠癌中MEOX2的表达水平。方法纳入2022年4月-6月于承德医学院附属医院胃肠外科接受结直肠癌切除术的患者30例，Western blot及免疫组化检测癌组织及邻近癌旁组织中MEOX2蛋白的表达水平。结果 MEOX2主要在细胞核表达，在结直肠癌中阳性表达率为93%（28/30），而癌旁组织中表达MEOX2的比例为13%（4/30）（P＜0.01）。Western blot结果也显示MEOX2蛋白在结直肠癌组织中高表达（P＜0.05）。结论 MEOX2在结直肠癌患者癌组织中表达升高，可能与结直肠癌发生发展相关；为探索结直肠癌新的诊断性生物标志物提供新的方向。

Keywords

结直肠癌；间充质同源盒；MEOX2

References

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