[1] FENG Y, SHI Q, DING Y, et al. The prevalence and characterization of self-perceived sensitive facial skin among Freshmen in Urumqi, China [J]. J Cosmet Dermatol, 2022, 21(6): 2516-2522. 
[2] REICH A, WóJCIK-MACIEJEWICZ A, SLOMINSKI A T. Stress and the skin [J]. G Ital Dermatol Venereol, 2010, 145(2): 213-219. 
[3] CRITCHLEY H D, GARFINKEL S N. Interoception and emotion [J]. Curr Opin Psychol, 2017, 17: 7-14. 
[4] PHELPS E A, LEDOUX J E. Contributions of the Amygdala to Emotion Processing: From Animal Models to Human Behavior [J]. Neuron, 2005, 48(2): 175-187.
[5] RONG J, LAN L, JIE Z. The Trinity of Skin: Skin Homeostasis as a Neuro–Endocrine–Immune Organ [J]. Life, 2022, 12(5): 725-725. 
[6] BENTO-LOPES L, CABAçO L C, CHARNECA J, et al. Melanin’s Journey from Melanocytes to Keratinocytes: Uncovering the Molecular Mechanisms of Melanin Transfer and Processing [J]. International Journal of Molecular Sciences, 2023, 24(14): 11289. 
[7] CATHERINE P-S. [Histology of skin and hair follicle] [J]. Medecine sciences : M/S, 2006, 22(2): 131-137. 
[8] M O D, A L E. Diversification and specialization of touch receptors in skin [J]. Cold Spring Harbor perspectives in medicine, 2014, 4(6): a013656. 
[9] ZORINA A, ZORIN V, KUDLAY D, et al. Age-Related Changes in the Fibroblastic Differon of the Dermis: Role in Skin Aging [J]. International Journal of Molecular Sciences, 2022, 23(11): 6135. 
[10] ZHAO X, PSARIANOS P, GHORAIE L S, et al. Metabolic regulation of dermal fibroblasts contributes to skin extracellular matrix homeostasis and fibrosis [J]. Nature Metabolism, 2019, 1(1): 147-157. [11] KURINA L M, GOLDACRE M J, YEATES D. Depression and anxiety in people with inflammatory bowel disease [J]. Journal of Epidemiology & Community Health, 2001, 55(10): 716-720. 
[12] TOMIYAMA A J. Stress and Obesity [J]. Annual Review of Psychology, 2019, 70(Volume 70, 2019): 703-718. 
[13] ANABEL E, ITAY R, LIAT S, et al. Stress and cancer: mechanisms, significance and future directions [J]. Nature reviews Cancer, 2021, 21(12): 767-785. 
[14] FERENTINOS P, KALOGEROPOULOU E, PAPPA G, et al. Assessing the role of stressful life events in the induction and recurrence of alopecia areata: A case-control study [J]. J Am Acad Dermatol, 2022, 87(5): 1215-1217. [15] SHEN M, YANGJIAN XIAO B S, YAN YUAN B S, et al. Perceived stress links income loss and urticaria activity during the coronavirus disease 2019 pandemic [J]. Annals of Allergy, Asthma & Immunology, 2021, 126(1): 89-90. [16] SCHöN M P, BOEHNCKE W H. Psoriasis [J]. N Engl J Med, 2005, 352(18): 1899-1912. 
[17] DHABHAR F S. Stress, leukocyte trafficking, and the augmentation of skin immune function [J]. Ann N Y Acad, 2010, 992(1): 205-217. 
[18] A S. On the role of the corticotropin-releasing hormone signalling system in the aetiology of inflammatory skin disorders [J]. The British journal of dermatology, 2009, 160(2): 229-232. 
[19] PADGETT D A, MARUCHA P T, SHERIDAN J F. Restraint stress slows cutaneous wound healing in mice [J]. Brain Behavior and Immunity, 1998, 12(1): 64-73. 
[20] HüBNER G, BRAUCHLE M, SMOLA H, et al. Differential regulation of pro-inflammatory cytokines during wound healing in normal and glucocorticoid-treated mice [J]. Cytokine, 1996, 8(7): 548. 
[21] ROEL D R, DAVID M, BRIAN K, et al. Exercise and circadian rhythm-induced variations in plasma cortisol differentially regulate interleukin-1 beta (IL-1 beta), IL-6, and tumor necrosis factor-alpha (TNF alpha) production in humans: high sensitivity of TNF alpha and resistance of IL-6 [J]. J Clin Endocrinol Metab, 1997, (7): 7. 
[22] KAO J. Short-term glucocorticoid treatment compromises both permeability barrier homeostasis and stratum corneum integrity: inhibition of epidermal lipid synthesis accounts for functional abnormalities [J]. Journal of Investigative Dermatology, 2003, 120(3): 456-464. 
[23] JAY C S, DONGHYE K, JUNG K E, et al. Psychological Stress Deteriorates Skin Barrier Function by Activating 11β-Hydroxysteroid Dehydrogenase 1 and the HPA Axis [J]. Scientific reports, 2018, 8(1): 6334. 
[24] SCHALLREUTER K U, WOOD J M, LEMKE R, et al. Production of catecholamines in the human epidermis [J]. Biochemical & Biophysical Research Communications, 1992, 189(1): 72-78. 
[25] P O L A, M F J, E P C. Beta-Adrenoceptor Activation Reduces Both Dermal Microvascular Endothelial Cell Migration via a cAMPDependent Mechanism and Wound Angiogenesis [J]. Journal of Cellular Physiology, 2015, 230(2): 356-365. 
[26] ALLEN J A, RODDIE I C. The role of circulating catecholamines in sweat production in man [J]. The Journal of Physiology, 1972, 227(3): 801-814. 
[27] SCHUT C, MOLLANAZAR N K, SETHI M, et al. Psychological Stress and Skin Symptoms in College Students: Results of a Crosssectional Web-based Questionnaire Study [J]. Acta Derm Venereol, 2016, 96(4): 550-551. 
[28] LUCA M D, SIEGRIST W, BONDANZA S, et al. α-Melanocyte stimulating hormone (MSH) stimulates normal human melanocyte growth by binding to high affinity receptors [J]. Journal of Cell Science, 1993, 105 ( Pt 4)(4): 1079-1084. 
[29] HUNT G, DONATIEN P D, CRESSWELL J E, et al. The Effect of ?-MSH on the Attachment of Human Melanocytes to Laminin and Fibronectin: Evidence for Specific ?-MSH Receptors on These Cells [J]. Annals of the New York Academy of Sciences, 1993, 680(1): 549. 
[30] ZHANG L, LI W H, ANTHONAVAGE M, et al. Melanocortin-5 receptor and sebogenesis [J]. European journal of pharmacology, 2011, 660(1): 202-206. 
[31] T S A, A Z M, CEZARY S, et al. Sensing the environment: regulation of local and global homeostasis by the skin’s neuroendocrine system [J]. Advances in anatomy, embryology, and cell biology, 2012, 212: v, vii, 1-115. [32] ASAHINA A, HOSOI J, GRABBE S, et al. Modulation of Langerhans cell function by epidermal nerves [J]. Journal of Allergy & Clinical Immunology, 1995, 96(6): 1178-1182. [33] CUMBERBATCH M, DEARMAN R J, GRIFFITHS C E M, et al. Epidermal Langerhans cell migration and sensitisation to chemical allergens [J]. Apmis, 2010, 111(7-8): 797-804. 
[34] MAHMOUD G E B, LAURA D, HANINE H, et al. Nerve growth factor and burn wound healing: Update of molecular interactions with skin cells [J]. Burns : journal of the International Society for Burn Injuries, 2022, 49(5): 989-1002. 
[35] YAAR, M. Evidence for nerve growth factor-mediated paracrine effects in human epidermis [J]. The Journal of Cell Biology, 1991, 115(3): 821-828. [36] LAURENT M, OPHéLIE P, CHRISTELLE L G, et al. Basic mechanisms of itch [J]. The Journal of allergy and clinical immunology, 2023, 152(1): 11-23. 
[37] GRANDO S A, PITTELKOW M R, SCHALLREUTER K U. Adrenergic and Cholinergic Control in the Biology of Epidermis: Physiological and Clinical Significance [J]. Journal of Investigative Dermatology, 2006, 126(9): 1948-1965. 
[38] KOIZUMI H, TANAKA H, OHKAWARA A. beta-Adrenergic stimulation induces activation of protein kinase C and inositol 1,4,5-trisphosphate increase in epidermis [J]. Experimental Dermatology, 2010, 6(3): 128-132. 
[39] BIKLE D D, MAURO T M. Calcium, Orai1, and Epidermal Proliferation [J]. Journal of Investigative Dermatology, 2014, 134(6): 1506-1508. 
[40] BRUNA R, LIN C, A D L. Repeated stress-induced crosstalk between the sympathetic nervous system and mast cells contributes to delayed cutaneous wound healing in mice [J]. Journal of neuroimmunology, 2023, 379: 578104-578104. 
[41] EUN C M, HANJU Y, HARI L, et al. Carvedilol, an Adrenergic Blocker, Suppresses Melanin Synthesis by Inhibiting the cAMP/CREB Signaling Pathway in Human Melanocytes and Ex Vivo Human Skin Culture [J]. International Journal of Molecular Sciences, 2020, 21(22): 8796-. 
[42] BERTOLOTTO, C. Microphthalmia Gene Product as a Signal Transducer in cAMP-Induced Differentiation of Melanocytes [J]. The Journal of Cell Biology, 1998, 142(3): 827-835. 
[43] TZU-KAI, LIN, LILY, et al. Association between Stress and the HPA Axis in the Atopic Dermatitis [J]. International Journal of Molecular Sciences, 2017, 18(10): 2131. 
[44] SLOMINSKI A, ZBYTEK B, SZCZESNIEWSKI A, et al. CRH stimulation of corticosteroids production in melanocytes is mediated by ACTH [J]. Am J Physiol Endocrinol Metab, 2005, 288(4): E701. 
[45] A S, B Z, A P, et al. CRH functions as a growth factor/cytokine in the skin [J]. Journal of Cellular Physiology, 2006, 206(3): 780-791. 
[46] PASTAR I, STOJADINOVIC O, YIN N C, et al. Epithelialization in Wound Healing: A Comprehensive Review [J]. Advances in Wound Care, 2014, 3(7): 445. 
[47] KIM J E, CHO B K, CHO D H, et al. Expression of Hypothalamic-Pituitary-Adrenal Axis in Common Skin Diseases: Evidence of its Association with Stress-related Disease Activity [J]. Acta dermato-venereologica, 2013, 93(4): 387-393. 
[48] JOZIC I, STOJADINOVIC O ,KIRSNER S R , et al.Skin under the (Spot)-Light: Cross-Talk with the Central Hypothalamic– Pituitary–Adrenal (HPA) Axis[J].Journal of Investigative Dermatolo gy,2015,135(6):1469-1471. 
[49] WEXNER, LOIS B. The degree to which colors (hues) are associated with mood-tones [J]. Journal of Applied Psychology, 1954, 38(6): 432-435. 
[50] ILONA C, D’ A S, HåKAN O. Reduced pleasant touch appraisal in the presence of a disgusting odor [J]. Plos One, 2014, 9(3): e92975. 
[51] JINYOUNG S, SUBIN C, HYEYOUN K, et al. Association between Olfactory Receptors and Skin Physiology [J]. Annals of dermatology, 2022, 34(2): 87-94. 
[52] HA C J, GU L H, YOUNG L S, et al. Iris Pallida Extract Alleviates Cortisol-Induced Decrease in Type 1 Collagen and Hyaluronic Acid Syntheses in Human Skin Cells [J]. Current Issues in Molecular Biology, 2023, 45(1): 353-363. 
[53] M M, M V, H H. Clinical Applications of Saffron (Crocus sativus) and its Constituents: A Review [J]. Drug research, 2015, 65(6): 287- 295. 
[54] MZABRI, ADDI, BERRICHI. Traditional and Modern Uses of Saffron (Crocus Sativus) [J]. Cosmetics, 2019, 6(4): 63. 
[55] MINGWU D, DONG L, YICHEN Z, et al. Protective effect of crocin on ultraviolet B-induced dermal fibroblast photoaging [J]. Molecular medicine reports, 2018, 18(2): 1439-1446.