Volume 2,Issue 3
Fall 2025
皮脂代谢的全周期调控机制与干预靶点综述
皮脂是由皮脂腺分泌的复杂脂质混合物,参与维持皮肤屏障、调节水分、抗菌和缓冲外界刺激。皮脂代谢涉及多层级、多靶点信号通路,调控机制复杂且个体差异明显。本文系统梳理皮脂合成、分泌、降解等生理过程,阐明了皮脂代谢紊乱对皮肤健康的影响,并重点解析了PPARγ、雄激素信号、SREBP转录因子及脂滴自噬等关键调控环节,同时综述了相应的潜在干预靶点。构建“源头— 前端— 中端— 终端— 末端”的全周期调控框架,为精准控油策略及功能性护肤产品研发提供理论依据和实践指导。
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