Volume 2,Issue 3
Fall 2025
神经酰胺在治疗皮肤疾病方面的研究进展
神经酰胺作为角质层的主要脂质成分(约占30%~50%),是皮肤屏障功能的关键成分。其独特的“亲水头部— 疏水尾部”分子结构,协同胆固醇与游离脂肪酸形成层状脂质膜,维持表皮水合状态并防止经皮水分丢失(TEWL)。近年来研究揭示,神经酰胺的含量异常会引起皮肤屏障功能缺陷的相关疾病,如特应性皮炎、银屑病、痤疮、鱼鳞病等。本文就神经酰胺与皮肤疾病的关系及其在治疗相关皮肤疾病方面的作用研究进展进行综述。
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