Volume 3,Issue 1
玫瑰PDRN的提取及其抗衰修护功效研究
文章针对玫瑰中多聚脱氧核糖核苷酸（PDRN）开展提取工艺研究并探究其抗衰修护功效。通过冻干-研磨预处理、酶解破壁、Sevag 法除杂及乙醇沉淀分步提取，获玫瑰 PDRN 粗品，得率（5±0.08）mg/g。抗衰实验显示，其可显著促进人皮肤成纤维细胞增殖，上调 COL1A1、COL3A1 表达，下调 MMP-1 表达，且显著降低 DPPH 水平（P<0.05）；修护实验表明，其能显著促进 HaCaT 细胞迁移（P<0.01）。文章建立玫瑰 PDRN 标准化提取流程，为其在抗衰修护类化妆品中的应用提供了功效依据。
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