Art and Design / CDCST / Volume 1 / Issue 2 / DOI: 10.61369/CDCST.7983
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基于网络药理学及体外实验探究中草药组方协同调节皮肤老化的作用机制

春波 冯
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1 上海家化联合股份有限公司研发中心, 上海家化联合股份有限公司研发中心
CDCST 2024 , 1(2), 1–7;
Published: 25 November 2024
© 2024 by the Author. Licensee Art and Design, USA. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC BY-NC 4.0) ( https://creativecommons.org/licenses/by-nc/4.0/ )
Abstract

人体皮肤结构和稳态平衡被破坏的主要原因有真皮层细胞外基质蛋白降解、DNA损伤和氧化应激等因素。本文采用有皮肤抗衰老性能报道的中草药(Traditional Chinese Medicine ,TCM),探索其不同组合的组方,包括人参、黄精、桂花、昙花和莲,基于网络药理学预测不同TCM组方的潜在功效靶点和抗衰老机制,比较了不同组方在皮肤中的生物活性组间区别,探究了不同组方中草药的抗衰老效果。通过体外实验多维度验证不同组方在相同浓度下的协同作用。结果显示,五味中草药组方比人参、黄精、昙花三味组方以及单味人参,具有在胶原蛋白促生、SA-β-半乳糖苷酶降低、γH2AX诱导的DNA损伤降低等方面更强的抗皮肤衰老效果。

Keywords
中草药组分
中草药提取物组方
网络药理学
皮肤衰老
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China Daily Chemical Science Technology, Electronic ISSN: 2997-710X Print ISSN: 2997-7096, Published by Art and Design