ARTICLE
5 March 2026

视黄醇保护和甲氧基肉桂酸辛酯皮肤输送的自组装溶性液晶凝胶体系研究

倡 许1 旭泽 柳2 虎君 许2
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1 苏州懋业生物科技有限公司, 中国
2 江南大学化工学院, 中国
CDCST 2026 , 3(1), 17–22; https://doi.org/10.61369/CDCST.2026010004
© 2026 by the authors. Licensee Art and Technology, USA. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC BY-NC 4.0) ( https://creativecommons.org/licenses/by-nc/4.0/ )
Abstract

通过十二、十四烷基糖苷硫酸酯钠(APGS-Na)水溶液及油酸-聚乙二醇400(PEG400)混合相制备溶质液晶(LLCs)凝胶,作为视黄醇与对甲氧基肉桂酸辛酯(OMC)的包封体系,对该体系液晶行为进行表征,并测定其包封视黄醇的降解率、包封OMC的皮肤渗透及保留能力。结果显示该液晶凝胶的结构为层状中间相,且液晶凝胶包封体系降低了视黄醇降解率,同时OMC在角质层的保留率是表皮和真皮层的3倍,证明该液晶凝胶体系有效抑制了视黄醇的降解及OMC的体外释放。

Keywords
液晶凝胶
视黄醇保护
甲氧基肉桂酸辛酯
皮肤输送
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