Volume 2,Issue 3
软骨素硫酸钠在皮肤护理方面的应用和展望
软骨素硫酸钠是一种酸性黏多糖,广泛存在于人和动物软骨组织中。其主要在改善关节功能、减轻疼痛,并且还在抗凝血、降血脂以及促进角膜修复等方面发挥作用。文章基于中国知网、Webof Science和Pubmed等数据库相关文章,综述了软骨素硫酸钠的理化性质、制备纯化、毒理学数据、在改善皮肤方面的功效及其在化妆品领域的应用前景,以期为软骨素硫酸钠在化妆品领域的应用提供理论参考。
[1]HSU HC, KE YL, LAI YH, et al. Chondroitin sulfate enhances proliferation and migration via inducing beta-catenin and intracellular ROS as well as suppressing metalloproteinases through Akt/NFkappaB pathway inhibition in human chondrocytes[J]. J Nutr Health Aging, 2022,26(3):307-313.
[2]ZHANG B, CHI L. Chondroitin sulfate/dermatan sulfateprotein interactions and their biological functions in human diseases: implications and analytical tools[J]. Front Cell Dev Biol,2021,9:693563.
[3]焦广飞. 鲨鱼硫酸软骨素二糖组成分析及其4S/6S比值的讨论[J]. 海峡药学, 2024,36(05):49-53.
[4]赵琳, 云振宇, 吴希, 等. 硫酸软骨素钠的制备及抗骨关节炎活性研究进展[J]. 医药导报, 2024,43(06):916-925.
[5]付常芳, 周伟, 高奇, 等. 硫酸软骨素及其衍生物研究进展[J].医药导报, 2023,42(05):688-691.
[6]LOMONTE A, MENDONCA JA, DE CASTRO B G, et al. Multicenter, randomized, double-blind clinical trial to evaluate efficacy and safety of combined glucosamine sulfate and chondroitin sulfate capsules for treating knee osteoarthritis[J]. Adv Rheumatol,2018,58(1):41.
[7]MIRAGLIA N, BIANCHI D, TRENTIN A, et al. Safety assessment of non-animal chondroitin sulfate sodium: subchronic study in rats,genotoxicity tests and human bioavailability[J]. Food Chem Toxicol,2016,93:89-101.
[8]赵琳, 姜雨, 兰韬, 等. 硫酸软骨素钠质量安全标准及关键控制点研究进展[J]. 食品工业科技, 2022,43(19):7-13.
[9]王伙根, 罗程, 张森林. 低分子量硫酸软骨素研究现状[J]. 科技风, 2020(23):174-178.
[10]VOLPI N. Chondroitin sulfate safety and quality[J]. Molecules,2019,24(8).
[11]LI MN, JIA XZ, YAO QB, et al. Recent advance for animal-derived polysaccharides in nanomaterials[J]. Food Chem, 2024,459:140208.
[12]CORTES-MEDINA M, BUSHMAN AR, BESHAY PE, et al. Chondroitin sulfate, dermatan sulfate, and hyaluronic acid differentially
modify the biophysical properties of collagen-based hydrogels[J]. Acta Biomater, 2024,174:116-126.
[13]PAPAGIANNOPOULOS A, SKLAPANI A, SPILIOPOULOS N.Thermally stabilized chondroitin sulfate-hemoglobin nanoparticles
and their interaction with bioactive compounds[J]. Biophys Chem,2024,304:107127.
[14]姜玮, 王金凤, 张惠, 等. 硫酸软骨素生产工艺现状与解析[J].药物生物技术, 2015,22(02):185-188.
[15] YU J, XU J, JIANG R, et al. Versatile chondroitin sulfate-based nanoplatform for chemo-photodynamic therapy against triple-negative breast cancer[J]. Int J Biol Macromol, 2024,265(Pt 1):130709.
[16]SADEGHI A, ZANDI M, PEZESHKI-MODARESS M, et al.Tough, hybrid chondroitin sulfate nanofibers as a promising scaffold for skin tissue engineering[J]. Int J Biol Macromol, 2019,132:63-75.
[17]JABEEN N, SOHAIL M, SHAH SA, et al. Silymarin nanocrystalsladen chondroitin sulphate-based thermoreversible hydrogels; A
promising approach for bioavailability enhancement[J]. Int J Biol Macromol, 2022,218:456-472.
[18]国家药典委员会. 中华人民共和国药典(二部)[M]. 北京: 中国医药科技出版社, 2020.
[19] 王俊, 王紫薇, 张金木, 等. 不同来源和纯度的硫酸软骨素理化特性的研究[J]. 湖北农业科学, 2016,55(23):6224-6227.
[20]VOLPI N. Quality of different chondroitin sulfate preparations in relation to their therapeutic activity[J]. J Pharm Pharmacol,
2009,61(10):1271-1280.
[21]JORDAN KM, ARDEN NK, DOHERTY M, et al. Eular recommendations 2003: an evidence based approach to the management
of knee osteoarthritis: report of a task force of the standing committee for international clinical studies including therapeutic trials (escisit)[J].Ann Rheum Dis, 2003,62(12):1145-1155.
[22]MAZUKINA E, SHEKUNOVA E, KOSMAN V, et al. Preclinical study of the efficacy and safety of chondroitin sulfate[J]. Bezop. Risk Farmakoter, 2021,9(1):43-57.
[23] 谢艾伶, 刘全瑞, 魏勇跃, 等, 硫酸软骨素对雏鸡的急性毒性试验[J]. 黑龙江畜牧兽医, 2023(21):102-106+133-134.
[24] 徐冰, 王燕, 高慧艳, 等. 硫酸软骨素和氨基葡萄糖联合制剂的毒理学试验[J]. 河南预防医学杂志, 2017,28(6):405-409+ 431.
[25] 黄佳宁, 钟礼云, 陈秀锦, 等. 氨糖硫酸软骨素的亚急性毒性研究[J]. 海峡药学, 2019,31(8):44-47.
[26]IOVU M, DUMAIS G, DU SOUICH P. Anti-inflammatory activity of chondroitin sulfate[J]. Osteoarthritis Cartilage, 2008,16 (3):14-18.
[27]REN Z, JI Y, WANG Y, et al. Chondroitin sulfate from scophthalmus maximus for treating osteoarthritis[J]. Int J Biol
Macromol, 2018,108:1158-1164.
[28] 黄世玉, 李江森, 关瑞章, 等. 鲟鱼硫酸软骨素的免疫调节及抗炎抗过敏活性[J]. 中国生化药物杂志, 2012,33(05):540-543.
[29]郑丽, 王亚儿, 李和生. 乌贼硫酸软骨素的保水性、抗氧化性及抑制黑色素瘤生长的研究[J]. 现代食品科技, 2016,32(04):18-22.
[30] JEON H, SHIN YW, WON JG, et al. Novel cosmetic ingredient cs-aa polyion complex and skin moisturizing effect[J]. Skin Res
Technol, 2024,30(9):e70073.
[31]LIU Y, LV H, REN L, et al. Improving the moisturizing properties of collagen film by surface grafting of chondroitin sulfate for corneal tissue engineering[J]. J Biomater Sci Polym Ed, 2016,27(8):758-772.
[32]LAN R, LI Y, SHEN R, et al. Preparation of low-molecularweight chondroitin sulfates by complex enzyme hydrolysis and theirantioxidant activities[J]. Carbohydr Polym, 2020,241:116302.
[33]ZOU Z, WEI M, FANG J, et al. Preparation of chondroitin sulfates with different molecular weights from bovine nasal cartilage and their antioxidant activities[J]. Int J Biol Macromol, 2020,152:1047-1055.
[34]MEDEIROS L, VASCONCELOS B, SILVA MB, et al. Chondroitin sulfate from fish waste exhibits strong intracellular antioxidant
potential[J]. Braz J Med Biol Res, 2021,54(10):e10730.
[35]EGEA J, GARCIA AG, VERGES J, et al. Antioxidant, antiinflammatory and neuroprotective actions of chondroitin sulfate and
proteoglycans[J]. Osteoarthritis Cartilage, 2010,18(1):24-27.
[36]CAMPO GM, AVENOSO A, CAMPO S, et al. Administration of hyaluronic acid and chondroitin-4-sulfate limits endogenous
antioxidant depletion and reduces cell damage in experimental acute pancreatitis[J]. Pancreas, 2004,28(2):45-53.
[37]RONDANELLI M, MIRAGLIA N, PUTIGNANO P, et al. Shortand long-term effectiveness of supplementation with non-animal
chondroitin sulphate on inflammation, oxidative stress and functional status in obese subjects with moderate knee osteoarthritis before and after physical stress: a randomized, double-blind, placebo-controlled trial[J]. Antioxidants (Basel), 2020,9(12):1241.
[38]CAMPO GM, AVENOSO A, CAMPO S, et al. Antioxidant activity of chondroitin sulfate[J]. Adv Pharmacol, 2006,53:417-431.
[39]MIN D, PARK S, KIM H, et al. Potential anti-ageing effect of chondroitin sulphate through skin regeneration[J]. Int J Cosmet Sci,2020,42(5):520-527.
[40]GALVEZ-MARTIN P, SOTO-FERNANDEZ C, ROMERORUEDAJ, et al. A novel hyaluronic acid matrix ingredient with regenerative, anti-aging and antioxidant capacity[J]. Int J Mol Sci,2023,24(5).
[41] 徐丽萍, 姜喆, 姚鹏程, 等. 硫酸软骨素提取工艺优化及抑菌活性研究[J]. 哈尔滨商业大学学报(自然科学版), 2019,35(05):573-580.
[42]宫瑞泽, 王燕华, 孙印石. 不同加工方式及不同部位鹿茸中硫酸软骨素的含量分析[J]. 中国中药杂志, 2018,43(03):557-562.